Anti-hHR23b Antibody

This mouse monoclonal IgG2b antibody recognizes human hHR23b (UV excision repair protein RAD23 homolog B), a key component of the nucleotide excision repair machinery that detects UV-induced DNA lesions and shuttles ubiquitinated substrates to the proteasome. Raised against the human target, the unconjugated antibody from Antibodies.com supports multiple immunodetection workflows across species.

Validated applications include Western blot for analyzing hHR23b expression in cell lysates, immunocytochemistry on cultured cells, and immunohistochemistry on tissue sections. Cross-reactivity has been demonstrated in human, mouse, rat, and monkey samples, making the reagent useful for comparative DNA repair studies and translational research models. The antibody is supplied as 100 µl of reagent in a single-use vial format.

Suggested uses include investigations of UV-damage response, xeroderma pigmentosum pathways, proteasome-mediated protein degradation, and characterization of xeroderma pigmentosum group C (XPC) complex formation. Refrigerate at 4 °C for short-term storage or aliquot and freeze at lower temperature for long-term stability, preserving binding activity across multiple freeze-thaw cycles for research use only applications.