Anti-HFE2 Antibody

Targeting HFE2 (hemojuvelin), this unconjugated polyclonal antibody from Antibodies.com supports research into iron homeostasis and the genetic basis of juvenile hemochromatosis. Hemojuvelin acts as a bone morphogenetic protein co-receptor in the BMP-SMAD signaling axis that drives hepatic hepcidin expression, so dependable detection of the protein is central to studies of systemic iron loading, anemia of chronic disease, and related metabolic disorders.

Provided as 100 µl of liquid in a single vial and raised in rabbit, the reagent is validated for western blot and immunohistochemistry across human, mouse, and rat samples. The polyclonal format recognizes multiple epitopes on HFE2, improving the chance of detecting both the full-length membrane-bound form and its cleaved soluble fragment. Cross-reactivity across these three species also makes the antibody useful for translational comparisons between mouse disease models and human patient tissue. For handling, keep the vial refrigerated and prepare small working aliquots to minimize freeze-thaw cycles and preserve binding activity across multiple experiments.