Anti-Hexim1 Antibody

Raised in rabbit and affinity-purified as an unconjugated polyclonal reagent, this Antibodies.com antibody targets Hexim1, the hexamethylene-bisacetamide-inducible protein that sequesters the positive transcription elongation factor b (P-TEFb) inside the inactive 7SK small nuclear ribonucleoprotein complex, restraining RNA polymerase II processivity. The reagent is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA workflows, and cross-reacts with human, mouse, and rat samples, supporting comparative studies of transcriptional control across species. Supplied as a 100 µl liquid aliquot, the antibody provides enough material for multiple immunoblots, tissue staining experiments, and plate-based detection assays from a single vial. Investigators working on cardiac hypertrophy, embryonic development, glucocorticoid receptor signaling, and innate immunity rely on this reagent to monitor Hexim1 expression, localize the protein within nuclear speckles and the nucleoplasm, and follow the dynamic release of P-TEFb from the 7SK complex under stress, differentiation, or pharmacological perturbation.