Anti-HES5 Antibody

The HES5 target belongs to the basic helix-loop-helix (bHLH) family of transcriptional repressors that operate downstream of Notch receptor signaling. This unconjugated IgG polyclonal reagent is raised in rabbit and validated for Western blot detection of endogenous HES5 protein in human and mouse sample lysates, supporting research into neural stem cell maintenance, gliogenesis, and developmental patterning where HES5-mediated repression of proneural genes is well established.

Supplied as 200 µL of ready-to-use antibody, the reagent finds use in research-focused applications including immunoblotting of neural progenitor cell extracts and differentiated neuron cultures. Standard handling recommendations apply: aliquot upon arrival, store refrigerated, and protect from light to preserve reactivity across multiple freeze-thaw cycles, with brief ice-cold incubation during Western blot processing.

Each lot is quality-controlled to confirm specificity for HES5, helping investigators distinguish it from related bHLH factors such as HES1 and HEY1. For researchers tracking Notch pathway activity, this Antibodies.com reagent provides a focused tool for protein-level verification complementary to transcript-level qPCR studies.