Anti-Herpes Simplex Virus (HSV-ICP4) Antibody

This mouse monoclonal IgG antibody from Antibodies.com targets the Infected Cell Polypeptide 4 (ICP4) immediate-early transactivator of Herpes Simplex Virus, a 175 kDa nuclear phosphoprotein that drives early and late viral gene expression during the lytic cycle. Supplied at 500 µg of Protein G-purified antibody in unconjugated form for direct fluorophore or enzyme conjugation, the reagent is validated for Western blot detection of ICP4 in infected cell lyses and for immunofluorescence staining of viral replication compartments in cultured cells. End users aliquot the stock upon first thaw, store working aliquots frozen at -20 °C, and avoid repeated freeze-thaw cycles to preserve binding activity. Researchers in HSV-1 and HSV-2 pathogenesis, latency reactivation studies, antiviral compound screening, and recombinant virus reporter development apply ICP4-specific monoclonals to confirm productive infection and to distinguish immediate-early events from early and late gene programs in single-cycle growth curves.