Anti-Herpes Simplex Virus 2 (HSV 2-ICP27) Antibody

Antibodies.com supplies this Mouse monoclonal antibody directed against the ICP27 immediate-early regulatory protein of Herpes Simplex Virus type 2. ICP27 governs viral RNA processing, nuclear export, and the switch between early and late gene expression during the HSV-2 lytic cycle, so a reagent that specifically recognizes this target supports detailed mechanistic studies of herpesvirus replication and reactivation from latency.

Each vial contains 500 µg of Protein G-purified IgG in unconjugated format, ready for direct labeling or use with secondary detection reagents in standard immunodetection workflows. The antibody is validated for Western blot analysis of infected cell lysates and for immunofluorescence assay on fixed cells, allowing researchers to monitor ICP27 expression kinetics and visualize its subcellular distribution across the course of infection.

Typical applications include differentiation of HSV-2 from HSV-1 infection in cell culture models, characterization of antiviral compound effects on viral protein accumulation, and investigation of host-pathogen interactions during the immediate-early phase. The monoclonal format reduces lot-to-lot variability compared with polyclonal preparations and produces cleaner, more interpretable bands on Western blot and more consistent staining patterns by immunofluorescence.