Anti-Her3 / ErbB3 (Ab-1328) Antibody

Raised in rabbit and supplied as an unconjugated polyclonal antiserum, this primary antibody from Antibodies.com targets a region around tyrosine 1328 of the Her3 / ErbB3 receptor tyrosine kinase. The reagent is intended for detection of Her3 protein, including the activated, phosphorylated receptor species, in cell and tissue lysates by Western blot, and for antigen localization by immunohistochemistry on fixed sections. The antibody is validated for reactivity against human, mouse, and rat samples, and is supplied at 100 µl per vial, sufficient for several blotting or staining experiments. ErbB3 (also called HER3) is a member of the EGFR/ErbB family of receptor tyrosine kinases and is a focus of cancer research, particularly in HER2-amplified breast cancer, gastric cancer, and studies of acquired resistance to EGFR-targeted therapy, where Y1328 phosphorylation serves as a read-out of receptor activation downstream of heterodimerization with HER2. The unconjugated format allows end-users to pair the antibody with their preferred secondary reagent for chemiluminescent, fluorescent, or chromogenic detection workflows. Intended for research use only; not for diagnostic applications.