Anti-HER2 (Ab-1248) Antibody

Affinity-purified rabbit polyclonal reagent targeting HER2 (also called ERBB2, Neu, or HER-2/neu), the 185 kDa transmembrane receptor tyrosine kinase of the ErbB receptor family that is heavily studied in oncology and cell signaling research. From Antibodies.com, this unconjugated primary antibody is supplied as 100 µl and is validated for Western blot, immunohistochemistry, and immunofluorescence on human, mouse, and rat samples.

HER2 is encoded by the ERBB2 gene on chromosome 17q12, and amplification or overexpression of this receptor is one of the most clinically actionable findings in breast carcinoma research, with relevance to gastric, esophageal, and ovarian tumor models as well. The antibody recognizes the intracellular domain of the receptor and supports work in tumor tissue profiling, downstream signaling analysis across the PI3K-AKT and RAS-MAPK pathways, and preclinical evaluation of candidate HER2-directed inhibitors in cell culture and xenograft-derived material.

Each vial is intended for research use only. Recommended starting conditions differ by application; titration is advised for individual lysate and fixation conditions, and small aliquots should be refrigerated for routine use. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which can be advantageous when monitoring changes in receptor expression or post-translational modification across sample sets.