Anti-HDAC8 Antibody

Raised in rabbit and supplied as 100 µl of unconjugated polyclonal antiserum, this Antibodies.com primary antibody targets histone deacetylase 8 (HDAC8), a class I Zn2+-dependent deacetylase that removes acetyl groups from lysine residues on histone and non-histone substrates. The reagent is validated for Western blot and immunohistochemistry workflows and shows reactivity with Human, Mouse, and Rat samples, enabling comparative work across cell lines and tissue specimens.

HDAC8 is widely studied in oncology, with reported involvement in neuroblastoma and lymphoid malignancies, and in developmental biology as the gene mutated in Cornelia de Lange Syndrome. Researchers use the antibody to detect endogenous HDAC8 in lysates and fixed tissue sections, characterise chromatin remodelling and transcriptional repression programmes, and support pharmacology studies of deacetylase activity. Aliquot on first use, store refrigerated to preserve activity, and the reagent is intended for research use only.