Anti-HDAC8 Antibody

The HDAC8 protein belongs to the class I histone deacetylase family, enzymes that remove acetyl groups from lysine residues on histone and non-histone substrates to regulate chromatin structure and gene expression. Aberrant HDAC8 activity has been documented in T-cell lymphoma, neuroblastoma, and several other malignancies, making it an active target in epigenetic and oncology research.

This unconjugated rabbit polyclonal IgG reagent is supplied as 100 µl of liquid in a vial and is validated for Western blot and immunoprecipitation workflows. The antibody recognizes the HDAC8 target in human, mouse, and rat samples, supporting cross-species studies in cell lysate and tissue-derived preparations. Aliquot upon arrival and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve reactivity; this product is intended for research use only.

Manufactured by Antibodies.com, the polyclonal antibody is raised in a rabbit host and offers broader epitope coverage than monoclonal alternatives, an advantage when probing denatured HDAC8 in western blot applications.