Anti-HDAC7 Antibody

This rabbit polyclonal reagent from Antibodies.com targets HDAC7 (Histone Deacetylase 7), a class IIa deacetylase implicated in transcriptional repression, vascular development, and T-lymphocyte signaling. The antibody is supplied unconjugated in a 50 µl vial, with western blot (WB) and immunohistochemistry (IHC) workflows among its validated uses. It was raised against recombinant HDAC7 sequences and detects the protein in human, mouse, and rat samples, providing cross-species utility for translational research projects. HDAC7 shuttles between the cytoplasm and nucleus under the control of phosphorylation by PKD/PKC pathways, where it forms complexes with co-repressors such as NCoR/SMRT and MEF2 transcription factors to modulate chromatin accessibility at target gene promoters. Researchers studying cancer cell migration, endothelial inflammation, or immune cell differentiation routinely probe HDAC7 expression with this antibody. Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles and preserve titer for repeat experiments. Each lot is affinity-purified and tested in WB and IHC to confirm consistent performance, with the unconjugated format allowing end-users to conjugate to HRP, biotin, or fluorophores depending on their detection chemistry. The reagent is intended for research use only.