Anti-HDAC6 Antibody

Raised in rabbit and supplied as an unconjugated polyclonal reagent from Antibodies.com, this antibody recognizes histone deacetylase 6 (HDAC6), a predominantly cytoplasmic class IIb deacetylase that governs microtubule acetylation, heat shock protein 90 client maturation, aggresome formation, and selective autophagy pathways. Validated for western blot, immunohistochemistry, and immunofluorescence workflows, the reagent detects the endogenous protein in human, mouse, and rat samples, supporting cross-species investigations of cytoskeletal remodeling, proteostasis, and stress response signaling.

Each vial contains 100 µl of antiserum with no fluorophore or enzyme conjugated, allowing researchers to pair it with their preferred secondary detection reagent for chromogenic, fluorescent, or chemiluminescent readouts. Published uses include probing acetylated tubulin networks in neuronal cultures, examining HDAC6 recruitment to stress granules under proteasome inhibition, and characterizing aberrant HDAC6 expression patterns in tumor biopsies and cell line panels.