Anti-HDAC5 Antibody

HDAC5 (Histone Deacetylase 5) is a class IIa chromatin-modifying enzyme that shuttles between the nucleus and cytoplasm in response to phosphorylation-dependent signaling. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is supplied in a 50 µl vial and is validated for Western blot (WB) and immunohistochemistry (IHC) on human samples. HDAC5 deacetylates histone and non-histone substrates, recruits co-repressor complexes to MEF2 target genes, and shapes transcriptional programs that govern cardiac hypertrophy, skeletal muscle differentiation, neuronal survival, and metabolic stress responses. The polyclonal format delivers multi-epitope recognition, which supports detection of post-translational modifications and expression dynamics across cell lines and tissue samples. Host species is rabbit, target species is human, and the unconjugated format allows labs to conjugate the antibody to enzymes, fluorophores, or beads to suit individualized detection workflows. The vial may be aliquoted to limit freeze-thaw cycles and preserve activity; refer to the product insert for storage temperature and handling guidance. Researchers in cardiovascular biology, neuroscience, oncology, and metabolic disease use this reagent to track endogenous HDAC5 abundance and subcellular localization in fixed tissue sections and lysed cell preparations.