Anti-HDAC5 Antibody

The HDAC5 target is a class IIa histone deacetylase involved in chromatin remodeling and transcriptional repression through deacetylation of lysine residues on histone and non-histone substrates. The rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl of unconjugated serum in liquid format and is validated for Western blotting, immunohistochemistry, and immunofluorescence workflows. It cross-reacts with Human, Mouse, and Rat samples, making it useful for translational and comparative studies of the heart, skeletal muscle, neurons, and chondrocytes where this chromatin-modifying enzyme is known to regulate myocyte enhancer factor-2 (MEF2)-driven gene programs. The antibody recognizes the full-length HDAC5 protein (~124 kDa) and is supplied in a vial suitable for both cell lysate analysis and fixed-tissue imaging. Researchers working on cardiac hypertrophy, neuronal stress signaling, and epigenetic regulation studies will find the broad mammalian reactivity particularly valuable for profiling endogenous expression levels across model systems.