Anti-HDAC5 Antibody

The HDAC5 antibody from Antibodies.com is a rabbit polyclonal reagent raised against Histone Deacetylase 5, a class IIa HDAC family member that regulates chromatin remodeling, transcriptional repression, and stress-responsive gene programs in cardiac myocytes, neurons, and skeletal muscle. Supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, this unconjugated antibody is validated for western blot, immunohistochemistry, and immunofluorescence detection of endogenous HDAC5 in human samples.

Researchers use this reagent to investigate HDAC5 nucleocytoplasmic shuttling, MEF2-dependent transcriptional control, and the role of class IIa deacetylases in pathological hypertrophy, neurodegeneration, and tumor progression pathways. The polyclonal format provides multi-epitope recognition useful when probing post-translational modifications such as phosphorylation at Ser259 and Ser498, regulatory sites that govern HDAC5 nuclear export and 14-3-3 protein binding.

Recommended handling: aliquot upon arrival to limit freeze-thaw cycles and store refrigerated, protected from light, to preserve the glycerol-stabilized formulation across extended experimental timelines. Suitable for chromatin immunoprecipitation adjunct work, subcellular localization studies, and signaling pathway dissection where an unconjugated primary reagent supports a wide choice of secondary antibody conjugates and detection chemistries.