Anti-HDAC4 Antibody

HDAC4 (Histone Deacetylase 4) belongs to the class IIa family of histone deacetylases and plays a central role in chromatin remodeling, transcription repression, and signal-dependent gene regulation. This rabbit polyclonal antibody from Antibodies.com is raised against the HDAC4 target and supplied as an unconjugated reagent in a 100 µl vial, ready for Western blot and ELISA workflows.

The antibody detects HDAC4 from human, mouse, and rat samples, supporting comparative studies that span multiple model organisms. HDAC4 shuttles between the nucleus and cytoplasm under phosphorylation control by kinases such as CaMK and PKD, and the reagent can be used to track expression changes during cardiac hypertrophy, skeletal muscle differentiation, and neuronal stress responses. Because HDAC4 deacetylates both histone substrates and non-histone partners such as MEF2 family transcription factors, the antibody is also a useful tool for probing pathways that link chromatin state to cell fate decisions.

Researchers investigating epigenetic modification, neuronal survival, or class IIa HDAC signaling will benefit from the polyclonal format, which recognizes multiple epitopes across the protein and improves sensitivity when probing full-length HDAC4 in research use only applications. The unconjugated preparation gives flexibility to pair the antibody with a secondary detection reagent of choice, and the 100 µl volume supports multiple replicate blots or a sustained ELISA titration series.