Anti-HDAC4 Antibody

HDAC4 (Histone Deacetylase 4) is a class IIa deacetylase that shuttles between the nucleus and cytoplasm and regulates gene expression through lysine deacetylation of histone and non-histone substrates. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied in a 100 µl vial and supports multiple applications including Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation (ChIP).

The antibody is raised against human HDAC4 and validated for reactivity with human samples, with the polyclonal format providing broader epitope coverage for detection of full-length HDAC4 (approximately 119 kDa) and its processed isoforms. Researchers use this reagent to probe acetylation-dependent signaling pathways, assess HDAC4 subcellular distribution, and map chromatin occupancy in ChIP-based experiments.

Because HDAC4 has documented roles in cardiac hypertrophy, neuronal survival, skeletal muscle differentiation, and several solid and hematological cancers, the antibody is broadly useful across cell biology, oncology, and neuroscience projects, including in vitro work with cultured cell lines. The recommended handling approach is to aliquot on arrival to limit freeze-thaw cycles and to store refrigerated when the vial is in active use.