Anti-HDAC4 Antibody

Produced in rabbit as a polyclonal IgG reagent, this unconjugated primary antibody targets Histone Deacetylase 4 (HDAC4), a class IIa deacetylase that shuttles between the nucleus and cytoplasm and modulates chromatin structure, gene transcription, and signal-dependent transcriptional repression.

Researchers use the reagent for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples, with reactivity confirmed against each of these species. The 50 µl liquid aliquot is supplied ready for dilution into standard immunostaining buffers, and the unconjugated format lets end users pair it with their own secondary detection reagents, including HRP, biotin, or fluorophore conjugates of choice.

From Antibodies.com, the antibody supports studies in neuroscience, cardiac development, muscle differentiation, and cancer epigenetics where HDAC4's regulation by SUMOylation, 14-3-3 binding, and repression of MEF2-driven transcription is under investigation.