Anti-HDAC3 Antibody

The histone deacetylase 3 (HDAC3) enzyme belongs to the class I family of chromatin-modifying factors and removes acetyl groups from lysine residues on histone and non-histone substrates, regulating gene expression, cell cycle progression, and chromatin architecture in mammalian cells.

From Antibodies.com, this polyclonal reagent is raised in rabbit against HDAC3 and is supplied unconjugated in a 100 µl vial, ready to pair with the secondary detection system of choice. It is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, supporting both expression-profiling and subcellular localization studies on human, mouse, and rat samples.

Affinity purification and routine quality control help ensure reproducible performance across immunoblotting and imaging experiments. Investigators rely on HDAC3 detection to interrogate NCoR/SMRT co-repressor complex recruitment, neuronal differentiation programs, hepatic and adipose metabolic regulation, and tumor suppressor pathways in which HDAC3 has been implicated. Aliquot upon first use and store at -20 °C with freeze-thaw cycles minimized to preserve antibody activity over long-term studies.