Anti-HDAC3 Antibody

HDAC3 (Histone Deacetylase 3) is a class I histone deacetylase enzyme that participates in chromatin remodeling, transcriptional repression, and the NCoR/SMRT co-repressor complex. This rabbit polyclonal antibody from Antibodies.com detects HDAC3 across human, mouse, and rat samples, supporting research into epigenetic regulation and gene expression control.

The unconjugated formulation allows flexible pairing with user-selected secondary reagents across multiple immunoassay formats. Validated applications include Western blot for expression profiling, immunohistochemistry (IHC) for tissue localization studies, immunofluorescence (IF) for subcellular distribution, immunoprecipitation (IP) for protein-protein interaction mapping, and chromatin immunoprecipitation (ChIP) for genomic occupancy studies.

Packaged as 100 µl aliquots, the antibody should be handled according to standard refrigerated storage to preserve activity. The polyclonal composition provides recognition of multiple epitopes, which can improve robustness in immunoprecipitation and ChIP workflows where native protein conformation is critical.

Investigators studying HDAC3 functions in metabolism, inflammation, oncology, and neurological pathways rely on this reagent for endogenous protein detection. The cross-species reactivity profile enables translational comparisons between rodent model systems and primary human specimens, making it useful for both basic mechanistic studies and disease-oriented research.