Anti-HDAC10 Antibody

Histone deacetylase 10 (HDAC10) is a class IIb zinc-dependent deacetylase that regulates autophagy, mitophagy, and the cellular response to oxidative stress, and altered HDAC10 expression has been documented in lung cancer, gastric cancer, and neuroblastoma research. HDAC10 is also unusual among histone deacetylases for its polyamine deacetylase activity, making the protein a target of interest in cell biology and oncology studies. This Antibodies.com reagent is a rabbit polyclonal IgG raised against HDAC10, supplied as 100 µl of unconjugated antibody validated for Western Blot analysis of human, mouse, and rat samples. Researchers use it to probe endogenous HDAC10 levels in cell lysates and tissue homogenates, supporting studies of gene regulation, the DNA damage response, and chemoresistance pathways where HDAC10 depletion has been linked to increased drug sensitivity. The antibody is provided in a vial format and should be handled with suitable short-term refrigerated storage, with freeze-thaw cycles minimized to preserve binding activity. Aliquoting on first use is recommended for downstream blotting experiments that demand consistent signal-to-noise across replicates.