Anti-HDAC1 (phospho-S421) Antibody

Phospho-specific detection of HDAC1 at serine 421 is supported by this rabbit polyclonal reagent from Antibodies.com, which selectively binds the phosphorylated form of histone deacetylase 1, an enzyme central to chromatin remodeling and gene expression control. The antibody is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, in a 100 µl vial sized for multiple western blot and immunohistochemistry experiments. Confirmed reactivity with Human, Mouse, and Rat samples makes this unconjugated antibody a practical choice for comparative cell signaling, epigenetics, and oncology studies, where altered HDAC1 phosphorylation has been linked to proliferation, differentiation, and tumor progression pathways. Researchers can apply the antibody directly to PVDF or nitrocellulose membranes for western blot or to fixed tissue sections for IHC, and the polyclonal format increases tolerance for minor variations in sample preparation.