Anti-HDAC1 (phospho-S421/423) Antibody

Histone deacetylase 1 phosphorylated at serines 421 and 423 is detected by this rabbit polyclonal antibody from Antibodies.com. The dual phosphorylation marks a 14-3-3 binding motif generated during ATM-dependent DNA damage signaling and has been studied in the context of chromatin remodeling, cell cycle checkpoints, and tumor suppressor pathways.

Supplied as 100 µl of an unconjugated polyclonal reagent at 1 mg/ml in phosphate buffered saline (pH 7.2) with 0.05% sodium azide, the antibody has been validated for immunohistochemistry and shows reactivity with Human, Mouse, and Rat samples. It is intended for research use only, supporting studies in cancer epigenetics, genotoxic stress responses, and chromatin biology where phospho-specific detection of HDAC1 is required.