Anti-HDAC1 Antibody

Histone deacetylase 1 (HDAC1) is a class I chromatin-modifying enzyme that removes acetyl groups from lysine residues on histone and non-histone substrates, shaping chromatin accessibility and transcription. Produced in Rabbit as an unconjugated polyclonal reagent, this primary antibody is raised against HDAC1 and validated for Western blot and ELISA workflows across Human, Mouse, and Rat samples, making it a flexible tool for comparative studies in cell biology, neuroscience, and oncology research.

HDAC1 sits at the intersection of multiple signaling pathways: it partners with the NuRD and Sin3A co-repressor complexes, regulates the cell cycle and apoptosis, and is implicated in aberrant epigenetic silencing observed in many cancer types. Researchers use this Antibodies.com reagent to profile HDAC1 expression in tumor biopsies, to study acetylation-dependent transcription factors such as p53, and to investigate chromatin remodeling in Huntington's disease and other neurodegenerative models. The unconjugated format allows downstream pairing with HRP, fluorophore, or biotin labels of the researcher's choice.

Each vial is supplied as 100 µl of liquid antibody, suitable for multiple blotting experiments. For best results, store at -20 degrees C in working aliquots to limit freeze-thaw cycles, and protect from light if a conjugated secondary will be applied later. This reagent is intended for research use only and is not validated for diagnostic or therapeutic procedures.