Anti-HDAC1 Antibody

Histone deacetylase 1 sits at the center of chromatin remodeling and transcriptional repression, making this unconjugated rabbit polyclonal reagent a practical tool for tracking the enzyme across multiple experimental formats. Validated by Antibodies.com for western blot, immunohistochemistry, and ELISA workflows, the antibody recognizes human, mouse, and rat HDAC1, supporting cross-species studies in cancer biology, neurodegeneration, and epigenetic regulation. The 100 µl vial is supplied as a liquid stock suitable for dilution into standard blocking buffers, and the unconjugated format allows direct labeling or pairing with secondary detection chemistries tailored to each application. HDAC1 expression profiling in cell lysates and fixed tissue sections commonly uses this reagent at working concentrations optimized per application, with researchers exploiting its strong nuclear staining pattern in immunohistochemistry to distinguish proliferating from quiescent cell populations in tumor and developmental models. Because the target is a class I deacetylase that partners with Sin3, NuRD, and CoREST complexes, the polyclonal reagent is well suited to experiments probing chromatin state, histone acetylation dynamics, and gene silencing mechanisms in both cultured cells and primary tissue.