Anti-HDAC1 Antibody

Histone Deacetylase 1 (HDAC1) is a nuclear enzyme of approximately 55 kDa that catalyzes the removal of acetyl groups from lysine residues on core histones H3 and H4, and this rabbit polyclonal reagent from Antibodies.com is raised against that target for immunodetection in chromatin and epigenetic studies. HDAC1 plays a central role in chromatin remodeling, transcriptional repression, cell cycle progression, and the DNA damage response, and is widely studied in epigenetics, oncology, neuroscience, and stem cell research.

Supplied as a 100 µl unconjugated preparation, the antibody is suitable for direct use or for downstream labeling, and has been validated across multiple immunodetection workflows including Western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation (ChIP). It cross-reacts with Human, Mouse, and Rat samples, supporting comparative work across established model systems and primary tissues.

The reagent is useful for tracking HDAC1-dependent transcriptional programs, profiling histone modification patterns, and characterizing the recruitment of HDAC1-containing repressor complexes such as NuRD and Sin3A to chromatin under defined experimental conditions.