Anti-HCN1 Antibody

The HCN1 target is a hyperpolarization-activated cyclic nucleotide-gated cation channel that mediates the Ih current in neurons and helps set resting membrane potential and rhythmic pacemaker firing in excitable tissue. This rabbit polyclonal reagent from Antibodies.com recognizes HCN1 in human and mouse samples, supporting both Western blot and immunohistochemistry workflows on whole-cell lysates and fixed tissue sections.

Because the antibody is supplied in an unconjugated format, researchers can pair it with their preferred secondary detection system, whether HRP, biotin, or a fluorescent label, depending on the assay design. Each vial contains 100 µl of ready-to-dilute reagent suited to immunostaining of hippocampal and cortical neurons, where HCN1 is most abundantly expressed, as well as to probing channel protein levels in developmental or disease-model samples by Western blot.

Typical applications include mapping channel distribution across brain regions, validating heterologous expression in transfected cell lines, and screening for altered HCN1 abundance in models of epilepsy, neuropathic pain, and sinoatrial node dysfunction. Storage at 2 to 8 degrees C is recommended to preserve reagent performance for routine bench use.