Anti-HC-II (D68) Antibody

Heparin Cofactor II (HC-II) is a plasma serine protease inhibitor from the serpin superfamily that regulates thrombin activity in the presence of glycosaminoglycans, making this polyclonal antibody a useful reagent for vascular biology and coagulation research. Antibodies.com provides this Rabbit polyclonal antibody directed against the HC-II (D68) epitope, supplied as 100 µl of unconjugated antibody at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.2.

The reagent has been validated for Western blot (WB) and immunohistochemistry (IHC) applications and shows reactivity with human, mouse, and rat samples, supporting cross-species comparative studies. For routine handling, aliquot the stock to minimize freeze-thaw cycles and store refrigerated; long-term storage at -20 °C is recommended to preserve binding activity over time. The unconjugated format gives researchers flexibility to conjugate the antibody to custom fluorophores, enzymes, or beads, and the polyclonal nature allows simultaneous recognition of multiple epitopes on HC-II, which can improve signal detection when working with whole-cell lysates or fixed tissue sections.