Anti-HAS3 Antibody

Supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, this unconjugated rabbit polyclonal reagent from Antibodies.com is provided as a 100 µl vial. Raised against human hyaluronan synthase 3 (HAS3), it cross-reacts with mouse and rat orthologs and is validated for Western blot and immunohistochemistry on fixed and frozen tissue sections.

HAS3 is one of three transmembrane isoenzymes responsible for the biosynthesis of hyaluronan, a non-sulfated glycosaminoglycan implicated in extracellular matrix assembly, cell migration, and inflammatory signaling. Researchers investigating tumor microenvironments, wound repair, and epithelial differentiation routinely target this isoenzyme because its overexpression has been associated with aggressive cancer phenotypes and altered tissue hydration. The unconjugated format allows flexible pairing with secondary reagents, including HRP, fluorophore, or biotin conjugates, so the same primary can be redeployed across fluorescence, chromogenic, or affinity-based detection systems.

For storage, keep the vial at -20°C in single-use aliquots to minimize freeze-thaw cycles; the glycerol component provides protection during short-term handling at 4°C. Brief centrifugation prior to opening is recommended to recover the full volume and to reduce accidental loss during pipetting.