Anti-HAPLN1 Antibody [Assigned #A10828]

This rabbit monoclonal antibody from Antibodies.com targets HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1), an extracellular matrix component essential for stabilizing hyaluronan-proteoglycan aggregates in cartilage and connective tissues. The unconjugated IgG reagent, supplied as 50 µl, is validated for Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

HAPLN1 plays a central role in maintaining cartilage integrity by cross-linking aggrecan and other hyaluronic acid-binding proteoglycans, making it a valuable target for osteoarthritis and musculoskeletal research. The protein is also prominently expressed in developing heart valves, where it is required for proper valve morphogenesis, and it contributes to perineuronal net assembly in the central nervous system, supporting studies in cardiac development, neurobiology, and matrix biology. Recent investigations have also explored HAPLN1's involvement in melanoma metastasis and tumor microenvironment remodeling, broadening its relevance to cancer research.

Generated in rabbit with monoclonal specificity, this reagent provides batch-to-batch consistency for reproducible detection in tissue sections and protein lysate preparations. Researchers working on extracellular matrix assembly, aggrecan network stability, or connective tissue pathology will find this antibody a reliable tool for both basic and translational studies.