Anti-HAPLN1 Antibody

HAPLN1 (Hyaluronan And Proteoglycan Link Protein 1) is a key extracellular matrix component that stabilizes hyaluronic acid-proteoglycan aggregates, most notably in cartilaginous tissues and the nucleus pulposus of intervertebral discs. This polyclonal antibody, raised in rabbit, is supplied unconjugated at 1 mg/ml in a PBS buffer containing 0.1% sodium azide and 50% glycerol. The 100 µl volume is intended for Western blot and immunohistochemistry workflows against human, mouse, and rat samples. Researchers investigating cartilage biology, vertebral endplate development, or the molecular changes that accompany intervertebral disc degeneration use this reagent to localize HAPLN1 protein in tissue sections and to confirm expression changes in cell and tissue lysates. The antibody recognizes the native target in ECM-rich environments and is relevant for studies of spondyloepiphyseal dysplasia, where loss-of-function HAPLN1 variants disrupt matrix integrity. For long-term storage, aliquot and freeze at -20°C; protect from light and avoid repeated freeze-thaw cycles. Provided by Antibodies.com.