Anti-GYS1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets glycogen synthase 1 (GYS1), the muscle isoform of the rate-limiting enzyme that converts UDP-glucose into glycogen via α-1,4-glycosidic linkages. Raised in rabbit and supplied unconjugated in a 100 µl volume, the reagent is validated for Western blot and immunofluorescence workflows and shows reactivity with Human, Mouse, and Rat samples, supporting cross-species studies of muscle and cardiac glycogen metabolism. Because GYS1 activity is tightly controlled by hierarchical phosphorylation — including inhibitory sites such as Ser641 phosphorylated by GSK3 and activating sites such as Ser7 — researchers rely on isoform-specific detection to distinguish muscle-type glycogen synthesis from hepatic GYS2 activity, to probe insulin-stimulated glucose disposal in skeletal muscle, and to investigate glycogen storage disease type 0 and related metabolic phenotypes. The polyclonal format provides multiple epitope coverage, which is useful when probing post-translationally modified forms of the ~85 kDa protein or when working with denatured lysates in WB and fixed-cell imaging in IF.