Anti-GUSB Antibody

This rabbit polyclonal IgG reagent targets human beta-glucuronidase (GUSB), a lysosomal hydrolase that cleaves glucuronide conjugates and serves as a lineage marker for plasmacytoid dendritic cells and kidney proximal tubule epithelium. From Antibodies.com, the unconjugated antibody is supplied as 100 µl of liquid in a standard vial, ready for dilution into standard immunoblotting buffers and downstream HRP-conjugated detection chemistries.

Validated for Western blot on whole-cell lysates and tissue extracts, the reagent shows confirmed cross-reactivity with mouse and rat beta-glucuronidase orthologs alongside the human target, supporting comparative work across standard model organisms. GUSB loss-of-function variants cause mucopolysaccharidosis type VII (Sly syndrome), making reliable detection relevant to lysosomal storage disease research, studies of glycosaminoglycan catabolism, and investigations of enzyme-replacement therapy responses in relevant cell and tissue models.

For handling, aliquot upon arrival and store refrigerated; protect from repeated freeze-thaw cycles to preserve antibody activity across multiple experiments. Each lot is delivered as a polyclonal rabbit IgG preparation validated specifically for WB under the Antibodies.com quality program.