Anti-GUCY1B3 Antibody

This polyclonal antibody from Antibodies.com targets the beta 3 subunit of soluble guanylate cyclase (GUCY1B3), a key component of the nitric oxide–cGMP signaling pathway that mediates vascular smooth muscle relaxation and platelet aggregation. Raised in rabbit and supplied as the IgG isotype, the reagent is provided unconjugated in a 100 µl volume and validated for Western blot detection of the human protein in cell lysates and tissue homogenates. Investigators examining cardiovascular pharmacology, endothelial nitric oxide signaling, or pulmonary hypertension use this reagent to monitor sGC beta-subunit expression across experimental conditions. The unconjugated format supports downstream labeling with HRP, fluorophore, or biotin conjugates tailored to the chosen detection chemistry. Aliquoting upon arrival and storage at -20 °C between uses preserves antibody activity over multiple freeze-thaw cycles.