Anti-GTF2H2 Antibody

This rabbit polyclonal antibody targets GTF2H2, the p44 subunit of the general transcription factor IIH (TFIIH) complex. TFIIH is a multi-subunit assembly essential for RNA polymerase II transcription initiation and for nucleotide excision repair (NER) of UV-induced DNA lesions. GTF2H2 contributes to the kinase and helicase activities of TFIIH and anchors the complex to damaged DNA through its von Willebrand factor A-like domain.

Provided by Antibodies.com as an unconjugated IgG polyclonal reagent in a 100 µL volume, this antibody is validated for Western blot and immunohistochemistry workflows. It is raised in rabbit and detects endogenous GTF2H2 in human, mouse, and rat samples, supporting comparative studies across common model organisms.

Researchers working on transcription-coupled NER, xeroderma pigmentosum, trichothiodystrophy, and the cellular response to UV damage use this reagent to probe TFIIH subunit composition and stability in cell lysates and tissue sections. The polyclonal format increases the chance of recognizing GTF2H2 across multiple epitopes, which is helpful when working with post-translationally modified, truncated, or partially degraded samples.