Anti-GSTM1 Antibody

The polyclonal reagent from Antibodies.com targets Glutathione S-Transferase Mu 1 (GSTM1), a Phase II detoxification enzyme that conjugates reduced glutathione to electrophilic substrates, including environmental carcinogens, chemotherapeutic agents, and reactive oxygen species–derived compounds. Raised in rabbit, this unconjugated IgG antibody recognizes the human and mouse GSTM1 proteins and supports researchers studying xenobiotic metabolism, oxidative stress responses, and population-genetic analyses of the well-characterized GSTM1 null polymorphism, which epidemiology studies have linked to differential susceptibility to lung, bladder, and head-and-neck cancers.

Validated applications include western blot detection of the approximately 26 kDa GSTM1 monomer, immunohistochemistry on formalin-fixed paraffin-embedded tissue sections to map hepatic and epithelial expression patterns, and flow cytometry for intracellular staining experiments. Supplied as 200 µl of liquid aliquot, the antibody should be refrigerated at 4 °C, protected from light during handling, and shielded against multiple freeze-thaw cycles to preserve immunoglobulin activity. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which is particularly useful when characterizing samples that may carry deletions or polymorphic variants affecting antibody binding.

Investigators working on glutathione biology, toxicology screening panels, and pharmacogenomic biomarker discovery will find this unconjugated primary antibody a practical addition to standard immunodetection workflows.