Anti-GSTM1 Antibody

Glutathione S-transferase Mu 1 (GSTM1) is a cytosolic phase-2 detoxification enzyme that conjugates reduced glutathione to electrophilic substrates, including environmental carcinogens, xenobiotics, and several chemotherapeutic agents. This rabbit polyclonal IgG reagent from Antibodies.com binds the GSTM1 protein and is supplied as a 100 µL aliquot in unconjugated format, allowing researchers to choose secondary detection chemistry matched to their assay.

Validated applications include western blot analysis of the GSTM1 monomer in cell and tissue lysates, immunohistochemistry for staining distribution in formalin-fixed paraffin-embedded sections, and flow cytometry for intracellular detection in permeabilized cell populations. The polyclonal reagent recognizes GSTM1 in both human and mouse samples, supporting translational work on the GSTM1 null polymorphism, a widely studied germline deletion associated with modified risk profiles for lung, bladder, and head-and-neck cancers, as well as altered response to specific chemotherapy regimens.

Typical use cases extend across toxicology research, drug-metabolizing enzyme profiling, oxidative-stress studies, and biomarker characterization. Pair with standard anti-rabbit IgG secondary antibodies conjugated to HRP, biotin, or other fluorescent reporters depending on the application. The unconjugated polyclonal format also permits custom labeling workflows and supports immunoprecipitation protocols in which GSTM1-containing complexes are pulled down for downstream mass spectrometry or western blot identification.