Anti-GSS Antibody

The antibody targets glutathione synthetase (GSS), a mitochondrial enzyme that catalyzes the second ATP-dependent step in the de novo synthesis of glutathione from gamma-glutamylcysteine and glycine. GSS is broadly expressed across human, mouse, and rat tissues and is essential for maintaining intracellular redox balance and protecting cells from oxidative damage.

This rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, packaged as a 100 µl volume. It has been validated for western blot, immunohistochemistry, and immunofluorescence detection of the endogenous GSS protein in samples derived from human, mouse, and rat sources. The unconjugated format allows flexibility for downstream labeling with fluorophores, enzymes, or biotin according to experimental needs.

Glutathione synthetase plays a central role in cellular detoxification pathways and in maintaining the reduced glutathione pool. Alterations in GSS expression or activity are studied in contexts spanning oxidative stress and redox signaling research to investigations of inherited glutathione synthetase deficiency. Researchers working on antioxidant defense, redox homeostasis, and metabolic enzyme biology can use this antibody to monitor endogenous GSS protein levels across multiple model systems.