Anti-GSPT2 Antibody

Polyclonal antibodies from Antibodies.com, raised in rabbit against G1 to S phase transition protein 2 (GSPT2), support studies of translation termination and the G1/S checkpoint in mammalian cells. GSPT2, also referred to as eRF3B, associates with eRF1 to release nascent chains from the ribosome and contributes to nonsense-mediated mRNA decay, so reactivity across species enables comparative work between mouse models and human-derived samples. The unconjugated IgG reagent is supplied as a 200 µL liquid aliquot prepared for western blot workflows on lysates from human and mouse tissues. For handling, store the antibody at 4°C for short-term use or freeze aliquots at -20°C to preserve activity across freeze-thaw cycles, keeping each aliquot dedicated to single use to limit degradation. Researchers in cell-cycle biology, oncology, and translation control can use it to probe relative GSPT2 expression, isoform behavior, and the impact of small-molecule inhibitors on release-factor levels in vitro.