Anti-GSN Antibody

This rabbit polyclonal IgG antibody targets Gelsolin (GSN), a calcium-regulated actin-binding protein that severs and caps filamentous actin to remodel the cytoskeleton. Raised in rabbit and supplied unconjugated at 50 µl, the reagent is validated for Western blot and immunofluorescence workflows and cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies of cytoskeletal dynamics across species. Researchers use it to probe actin remodeling in cell migration, apoptosis, and signaling studies, as well as dysregulation of GSN that has been linked to cancer, neurodegeneration, and inflammatory conditions. The polyclonal format provides broader epitope coverage for detecting full-length GSN and major cleavage fragments, which is useful for tracking caspase-mediated cleavage events that produce biologically active fragments in models of programmed cell death. For best results, store at -20 °C in small working aliquots to limit freeze-thaw cycles and protect from light until use; this format is supplied as a single-use vial sized for routine immunoblotting and imaging experiments. Each preparation is provided by Antibodies.com as a research-use-only reagent intended for laboratory investigation of GSN expression and function in cell and tissue models.