Anti-GSK3B Antibody

Glycogen synthase kinase 3 beta (GSK3B) is a constitutively active serine/threonine protein kinase that plays central roles in multiple cellular pathways. This unconjugated rabbit polyclonal reagent from Antibodies.com is validated for western blot and immunohistochemistry workflows and detects the endogenous kinase in human, mouse, and rat tissue contexts. GSK3B regulates glycogen synthesis by phosphorylating glycogen synthase, participates in beta-catenin degradation within the canonical Wnt pathway, and phosphorylates tau protein at sites associated with neurofibrillary tangle formation in Alzheimer's disease research. Each vial contains 100 uL of polyclonal antiserum suitable for probing whole-cell lysates on PVDF or nitrocellulose membranes, as well as fixed paraffin-embedded sections following antigen retrieval. Store aliquots at -20 degrees C to preserve antibody activity across repeated freeze-thaw cycles. Researchers studying insulin signaling, neuronal development, mood disorder models, and oncology pathways rely on well-characterized GSK3B antibodies to map kinase expression changes across experimental conditions.