Anti-GSK3A (phospho S21) Antibody

This rabbit polyclonal IgG reagent from Antibodies.com is raised against glycogen synthase kinase 3 alpha (GSK3A) and selectively recognizes the kinase only when it is phosphorylated at serine 21, the N-terminal inhibitory site whose modification by AKT, p70 S6K, and other upstream kinases is used to read out PI3K/AKT, insulin, and Wnt pathway activity in cellular models.

Validated for western blot, immunohistochemistry, and immunofluorescence workflows on human, mouse, and rat samples, the unconjugated antibody is supplied as 50 µl of polyclonal serum and supports work on glycogen metabolism, tau hyperphosphorylation in neurodegeneration, growth-factor-driven signal transduction, and cancer cell lines in which phospho-state discrimination at S21 is critical to interpretation.