Anti-GSDMB Antibody

This unconjugated polyclonal antibody from Antibodies.com targets Gasdermin B (GSDMB), a pore-forming effector protein of the gasdermin family that has been implicated in pyroptotic cell death and mucosal epithelial biology. Raised in rabbit and supplied as 100 µl of IgG, the reagent is validated for Western blot detection of endogenous GSDMB in human, mouse, and rat samples. Published work links GSDMB activity to granzyme A cleavage by cytotoxic lymphocytes, to gasdermin-mediated killing of colorectal and gastric tumor cells, and to the 17q12 asthma-susceptibility locus, so the antibody fits studies in cancer immunotherapy, inflammasome-independent cytotoxicity, and airway inflammation. Suggested storage at -20 °C in single-use aliquots preserves reactivity across multiple freeze-thaw cycles, and the unconjugated format allows flexible pairing with HRP, fluorophore, or biotin secondary reagents in custom detection workflows.