Anti-GRP78 Antibody

This rabbit polyclonal antibody specifically targets GRP78 (Glucose-Regulated Protein 78), a 78 kDa endoplasmic reticulum-resident chaperone of the HSP70 family. Produced and validated by Antibodies.com, the reagent is supplied as an unconjugated antiserum in a 100 µl volume, ready for direct labeling or use in standard immunodetection workflows.

GRP78, also referred to as BiP or HSPA5, serves as a master regulator of the unfolded protein response and a widely recognized marker of endoplasmic reticulum stress. The antibody cross-reacts with samples from human, mouse, and rat, supporting investigations into proteostasis, cellular stress signaling, cancer biology, and neurodegeneration models.

Recommended applications include Western Blot for protein expression analysis, Immunohistochemistry for tissue localization studies, and Immunofluorescence for subcellular imaging. For optimal stability, aliquot upon arrival and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve binding activity over the shelf life of the reagent.