Anti-GRN Antibody

Progranulin (GRN) is a secreted glycoprotein widely studied for its roles in neurobiology, inflammation, and tissue repair, with heterozygous loss-of-function mutations linked to frontotemporal lobar degeneration. This rabbit polyclonal antibody from Antibodies.com is raised against GRN and validated for Western blot and immunohistochemistry on human and mouse samples. Supplied unconjugated at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl vial, it provides a flexible reagent for laboratories investigating progranulin expression, lysosomal trafficking, and inflammatory signaling. The polyclonal format enables recognition of multiple epitopes on the target, supporting reproducible detection in denaturing gels and fixed tissue sections. For best results, store at -20°C and aliquot to limit freeze-thaw cycles, thawing only what is needed for each experiment. Suited to neuroscience, oncology, and wound-healing research where species cross-reactivity between human and mouse specimens is essential, the reagent fits standard immunoblotting and IHC workflows without the need for a secondary conjugation step.