Anti-GRM8 Antibody

GRM8, also known as metabotropic glutamate receptor 8, is a class C G-protein coupled receptor that modulates presynaptic neurotransmitter release in the central nervous system. This rabbit-derived polyclonal reagent from Antibodies.com targets the human, mouse, and rat GRM8 protein, supporting neuroscience workflows that span rodent models and human tissue. The unconjugated antibody is provided as 100 µl of working solution and has been validated for western blot and immunohistochemistry, enabling detection of GRM8 expression in tissue sections and whole-cell lysates.

GRM8 has been investigated in pain signaling pathways, retinal circuitry, and certain psychiatric conditions, so a cross-reactive reagent detecting endogenous receptor levels in multiple species is useful for translational research. As a polyclonal reagent, the antibody recognizes multiple epitopes on GRM8, which can help when working with post-translationally modified receptor populations or splice variants that may not be captured by monoclonal binders.

Recommended storage is at -20°C in working aliquots to limit freeze-thaw cycles and preserve binding activity over the shelf life of the reagent. Researchers performing immunohistochemistry on rodent brain sections or western blot analysis of neural lysates will find this product compatible with standard immunodetection protocols, and the unconjugated format allows flexible pairing with user-preferred secondary antibodies and detection chemistries.