Anti-GRM8 Antibody

Raised in rabbit, this polyclonal reagent from Antibodies.com targets metabotropic glutamate receptor 8 (GRM8), a class C G protein-coupled receptor predominantly expressed in central nervous system tissue. Supplied as 100 µl of unconjugated antisera, it is validated for Western blot (WB) and immunohistochemistry (IHC) workflows across human, mouse, and rat samples.

GRM8 functions as a presynaptic inhibitory autoreceptor, modulating glutamate release at synapses in the cerebellum, hippocampus, and other brain regions. Investigators in neuropharmacology, synaptic plasticity, and disease modeling use this reagent to map receptor distribution, confirm knockdown or overexpression in transfected cell lines, and characterize expression changes in conditions such as epilepsy, anxiety-related behavior, and addiction.

The polyclonal format offers recognition of multiple epitopes, supporting reliable detection in denatured lysates on Western blot. For IHC, the antibody is applied to fixed tissue sections to localize GRM8 expression in neuronal populations. The unconjugated format allows users to pair the reagent with HRP, fluorescence, or chromogenic secondary antibodies matched to their preferred detection chemistry.

Each vial is supplied with a product datasheet outlining recommended starting dilutions and validation results. Aliquot on receipt and avoid repeated freeze-thaw cycles to preserve activity across multiple experiments.