Anti-GRM1 Antibody

Raised in rabbit against metabotropic glutamate receptor 1 (mGluR1), this unconjugated polyclonal antibody from Antibodies.com targets a class C G protein-coupled receptor that mediates slow excitatory glutamatergic transmission in the central nervous system. Supplied in a 100 µl vial and validated for western blot and immunohistochemistry workflows, it cross-reacts with human, mouse, and rat GRM1, supporting comparative studies across rodent models and human tissue specimens. Researchers commonly apply it to map mGluR1 distribution in cerebellar Purkinje cells, hippocampal neurons, and dorsal root ganglia, as well as to investigate aberrant GRM1 signaling in melanocytic lesions and melanoma cell lines where the receptor has been implicated as an oncogenic driver. For short-term use the vial should be kept refrigerated at 4°C; for longer storage it should be aliquoted and frozen at -20°C to minimize freeze-thaw loss of activity. The unconjugated format leaves the antibody available for downstream labeling with fluorophores, biotin, or HRP depending on the assay.