Anti-GRK6 Antibody

This polyclonal antibody from Antibodies.com targets G protein-coupled receptor kinase 6 (GRK6), a serine/threonine kinase that phosphorylates activated G protein-coupled receptors (GPCRs) and drives their desensitization and internalization. Raised in rabbit and supplied as an unconjugated reagent in a 100 µl volume, it is validated for Western blot (WB) and immunofluorescence (IF) workflows across human, mouse, and rat samples, supporting cross-species studies of GPCR signaling, chemokine receptor regulation, and downstream kinase activity.

GRK6 has been linked to leukocyte chemotaxis, dopamine receptor modulation, and several cancer pathways, making the antibody useful for investigating receptor turnover, β-arrestin recruitment dynamics, and phosphorylation-state analysis in cell lysates or fixed tissue. The polyclonal format provides recognition of multiple epitopes on GRK6, which can improve detection when expression levels are low or when probing for isoform-specific changes in primary cells and established lines.

Researchers studying GPCR desensitization, immune cell migration, or oncology-relevant kinase signaling can pair this reagent with standard immunoblotting buffers and immunofluorescence fixation protocols. The unconjugated format also allows users to couple the antibody to HRP, biotin, or fluorophores of their choice for custom detection setups in Western blot membranes, fixed-cell imaging, or immunoprecipitation follow-up experiments.