Anti-GRK6 Antibody

Raised in rabbit against G protein-coupled receptor kinase 6 (GRK6), this unconjugated polyclonal antibody from Antibodies.com is supplied as 100 µl at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol. The cryoprotectant blend stabilizes the immunoglobulin during refrigerated storage and limits damage across freeze-thaw cycles, while the azide component acts as a preservative for working aliquots kept at refrigerator temperature.

GRK6 is a serine/threonine kinase that phosphorylates ligand-bound G protein-coupled receptors, driving beta-arrestin recruitment, receptor desensitization, and clathrin-mediated internalization. The enzyme has documented roles in B-cell maturation, chemokine receptor downregulation, dopaminergic signaling, and neutrophil chemotaxis, and altered GRK6 expression has been reported in multiple myeloma and certain solid tumors, which is why researchers use validated anti-GRK6 reagents to probe receptor turnover and downstream signaling in cell biology and oncology workflows.

Validated for western blot, immunohistochemistry, and immunofluorescence, the reagent has been confirmed reactive against human, mouse, and rat samples, providing flexibility for cross-species studies of GPCR regulation in fixed tissue sections, cultured cells, and lysate preparations. It is intended for research use only as a primary detection reagent in immunostaining and immunoblotting protocols.